Stem cell proliferation, self-renewal and differentiation are regulated by a range of molecular mechanisms. Growth factors, transcription factors, and other components of signal transduction pathways all combine to coordinate cell behaviour. These signaling pathways can be modulated by naturally occurring and synthetic growth factors which bind to individual components of the pathway.
When binding causes modification of the target molecule's activity, the pathway can be disrupted. By targeting a particular pathway, it is possible to enhance stem cell proliferation and direct cell fate decisions.
Cell Guidance Systems offers a proprietary system that delivers a constant flow of growth factors called PODS Growth Factors.
The advantages of the PODS system include:
Slow-release depot formulation
Efficacious for weeks to months at 37oC
Non-denaturating production for superior bioactivity
Attaches readily to substrates for localized effects
Negligible batch variation
Manufactured in insect cells for important post-translational modifications
Animal-free manufacturing process
Stable storage at 4oC, no need to freeze or aliquot
Available in small, medium and large pack sizes
PODS can be used for a wide array of amplicantions, including:
- Physiological, stable gradient formation
- Bioinks for 3D printing
- Functionalizing scaffolds
- Microfluidics (lab on a chip)
- Improved and simplified stem cell culture
- Therapeutic protein delivery
To see the full list of growth factors available please vist the Custom Science store by clicking here.