• Reimagine2
  • Custom Panels
  • Clonal Genes
  • Gene Fragments
  • Variant Libraries

Technology Driven Synthesis

The Twist Bioscience DNA Synthesis Platform was developed to address the limitations of throughput, scalability and cost inherent in legacy DNA synthesis methods. By applying rigorous engineering principles to harness the highly-scalable production and processing infrastructure of the semiconductor industry allows us to achieve precision in manufacturing DNA at scale. We have industrialized the production of cost-effective, high-fidelity, high-throughput DNA.

Silicon-powered DNA synthesis

Twist Bioscience developed a proprietary semiconductor-based synthetic DNA manufacturing process featuring a high-throughput silicon platform that allows us to miniaturize the chemistry necessary for DNA synthesis. This miniaturization allows us to reduce the reaction volumes by a factor of 1,000,000 while increasing throughput by a factor of 1,000, enabling the synthesis of 9,600 genes on a single silicon chip at full scale. Traditional synthesis methods produce a single gene in the same physical space using a 96-well plate.